Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Robbie Amell Riley Frazier Guest Star Justin Bruening Hank Frazier Guest Star Christie Ann Burson Angela Kelly Guest Star Scott Lowell Guest Star Jarod Einsohn Nick Blount Guest Star Bonnie Burroughs Linda Frazier Guest Star Kathleen Munroe Guest Star Matt Medrano Guest Star Kodi Baker Lavin 43 Guest Star Annie Boon Superfan Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Aaron Rahsaan Thomas Writer Anthony Hemingway Director