Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Laura Benanti Anne Barker, Abigail Spencer Guest Star Sam Levine Graham Delancey Guest Star Noelle Beck Peri Delancey Guest Star Steve Greenstein Titus Delancey Guest Star Nancy Lemenager Susan Moore Guest Star Keesha Sharp Mistress Felicia Guest Star Patrick Kerr Simon Guest Star Paul Fitzgerald Burt Jeffries Guest Star Robert Emmet Lunney Attorney Guest Star Cindy Katz Marsha Whitaker Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer Liz Friedman Writer Andrew Bernstein Director