Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor, Director Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Desmond Harrington Michael Actor John Noble Morland Holmes Guest Star Julian Sands Jasper Wells Guest Star Stephen Spinella Merrick Hausmann Guest Star Dion Graham Hakeem Guest Star Jimmie Saito Blaine Geary Guest Star Dylan Baker Armand Venetto Guest Star Fedna Jacquet Ricky Guest Star Kyle Vincent Terry Angelo Guest Star Nadia Gan Kezzy Guest Star Lisa B. Tharps Female Surgeon Guest Star Pawel Szajda Vanja Borozan Guest Star Will Blum Melville Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Robert Hewitt Wolfe Writer