Goran Visnjic Dr. Luka Kovac Actor Maura Tierney Abby Lockhart Actor Mekhi Phifer Dr. Gregory Pratt Actor Parminder Nagra Dr. Neela Rasgotra Actor Linda Cardellini Nurse Samantha Taggart Actor Shane West Actor Scott Grimes Dr. Archie Morris Actor Laura Innes Dr. Kerry Weaver Actor John Stamos Dr. Tony Gates Actor Leland Orser Lyn Alicia Henderson ... Pamela Olbes Guest Star Stacy Keach Mike Gates Guest Star Chloe Greenfield Sarah Riley Guest Star Busy Philipps Hope Bobeck Guest Star Sean Blakemore Mario Guest Star J.P. Manoux Dr. Dustin Crenshaw Guest Star Vyto Ruginis Wright Guest Star Deezer D Nurse Malik McGrath Guest Star Troy Evans Frank Martin Guest Star Montae Russell Dwight Zadro Guest Star Christopher Chulack Executive Producer Michael Crichton Executive Producer David Zabel Executive Producer John Wells Executive Producer R. Scott Gemmill Executive Producer