Seth MacFarlane Peter Griffin , Brian Griffin , Stewie Griffin , Glenn Quagmire , Tom Tucker , Dr. Elmer Hartman , Additional Voices Voice, Executive Producer Alex Borstein Lois Griffin , Additional Voices Voice Seth Green Chris Griffin , Additional Voices Voice Mila Kunis Meg Griffin Voice Mike Henry Cleveland Brown , TV Announcer Voice Adam West Mayor Adam West, Himself Guest Voice Lori Alan Diane Simmons Guest Voice Brent Spiner Himself Guest Voice Denise Crosby Herself Guest Voice Gates McFadden Herself Guest Voice Jonathan Frakes Himself Guest Voice LeVar Burton Himself Guest Voice Marina Sirtis Herself Guest Voice Michael Dorn Himself Guest Voice Patrick Stewart Himself Guest Voice Wil Wheaton Himself Guest Voice Danny Smith Beer Can , Guy Guest Voice Alec Sulkin Announcer 10 , Co-Pilot , Jesus Christ , Trekkie 3 Guest Voice John Viener Announcer , Announcer 2 , Jagermeister , Lead Singer , Pilot Guest Voice Max Burkholder Calvin Guest Voice Patrick Meighan Jeremy Miller Guest Voice Steve Callaghan Employee Guest Voice Mark Hentemann Trekkie 2 Guest Voice Alexandra Breckenridge Hot Date Guest Voice Johnny Brennan Zima Bottle Guest Voice Chris Cox Kirk Cameron Guest Voice David Goodman Trekkie 2 Guest Voice Rob Lowe Himself Guest Voice David Zuckerman Executive Producer Greg Colton Director Peter Shin Director