Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Jean Smart Lana Gardner Guest Star Patricia Clarkson Claire French Guest Star Brian Klugman Kirby Guest Star Jonathan Ficcadenti Kirby's Friend Guest Star Christian Aubert Maitre'D Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Jon Sherman Writer