Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Patricia Clarkson Claire French Guest Star Jean Smart Lana Gardner Guest Star Regi Davis Hotel Manager Guest Star Bernard Addison Waiter Guest Star Terri Hoyos Hostess Guest Star Bebe Neuwirth Dr. Lilith Sternin Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer, Writer Dan O'Shannon Executive Producer Rob Hanning Writer