John Francis Daley Sam Weir Actor Linda Cardellini Lindsay Weir Actor Samm Levine Neal Schweiber Actor Martin Starr Bill Haverchuck Actor James Franco Daniel Desario Actor Jason Segel Nick Andopolis Actor Seth Rogen Ken Miller Actor Joe Flaherty Harold Weir Actor Becky Ann Baker Jean Weir Actor Busy Philipps Kim Kelly Guest Star Amy Aquino Mrs. Schweiber Guest Star Dave Allen Jeff Rosso Guest Star David Krumholtz Barry Schweiber Guest Star Sam McMurray Dr. Vic Schweiber Guest Star Shawnee Free Jones Jenna Zank Guest Star Judd Apatow Executive Producer Jake Kasdan Director Paul Feig Writer, Producer