Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Anna Maria Horsford Guest Star F.J. Rio Guest Star Rick Humphrey Guest Star Valerie Cruz Guest Star Taylor Nichols Guest Star Kate Burton Guest Star Tom Choi Guest Star Chris Hendrie Guest Star Moe Irvin Guest Star Helene McCardle Guest Star Jack Merrill Guest Star John O'Brien Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer Jim Parriott Executive Producer, Writer Adam Davidson Director