Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Jeffrey Dean Morgan Guest Star Becca Gardner Guest Star Stephen Spinella Guest Star Lauren Tom Guest Star John Prosky Guest Star Shannon Cochran Guest Star Kate Burton Guest Star Joyce Guy Guest Star Rob Narita Guest Star Linda Klein Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Kip Koenig Writer Jessica Yu Director