Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Chris O'Donnell Guest Star Sara Ramirez Guest Star Mare Winningham Guest Star Laurie Metcalf Guest Star Jeffrey Dean Morgan Guest Star Jeff Perry Guest Star Mandy Siegfried Guest Star Jusak Bernhard Guest Star Steven W. Bailey Guest Star Emilee Wallace Guest Star Harrison Knight Guest Star Soledad St. Hilaire Guest Star Obie Sims Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Blythe Robe Writer Seith Mann Director