Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Mark Pellegrino Guest Star Sandra Thigpen Guest Star Stephanie Childers Guest Star Steven M. Porter Guest Star Candice Afia Guest Star Amrapali Ambegaokar Guest Star Tymberlee Hill Guest Star Gloria Garayua Guest Star Molly Kidder Guest Star Richard Keith Guest Star Joy Osmanski Guest Star Winston Story Guest Star Joseph Williamson Guest Star Ariel Felix Guest Star Terrance Christopher Jones Guest Star John Cappon Guest Star Mac Brandt Guest Star Jaden Sorensen Guest Star Terrence Flack Guest Star Nadji Jeter Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Rob Corn Director