Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Amy Madigan Guest Star Lauren Stamile Guest Star John M. Jackson Guest Star Benjamin Ciaramello Guest Star Zilah Mendoza Guest Star David Giuntoli Guest Star Loretta Devine Guest Star Andre Ware Guest Star Joe Camareno Guest Star Bruce Katzman Guest Star Moe Irvin Guest Star Joseph Williamson Guest Star Candice Afia Guest Star Maria Elena Maglaris Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Tony Phelan Writer Joan Rater Writer Julie Anne Robinson Director