Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Jeffrey Dean Morgan Guest Star Eric Stoltz Guest Star Jessica Capshaw Guest Star Samantha Mathis Guest Star Perrey Reeves Guest Star Steven W. Bailey Guest Star Robin Pearson Rose Guest Star Melissa George Guest Star Aaron Refvem Guest Star John Sloman Guest Star Gloria Garayua Guest Star Molly Kidder Guest Star Candice Afia Guest Star Amrapali Ambegaokar Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Debora Cahn Writer Rob Corn Director