Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Jeffrey Dean Morgan Guest Star Jessica Capshaw Guest Star Amy Gumenick Guest Star Roberto Urbina Guest Star Robin Gwynne Guest Star Trent Gill Guest Star Mark Saul Guest Star Molly Kidder Guest Star Candice Afia Guest Star Mickey Maxwell Guest Star Amrapali Ambegaokar Guest Star Tymberlee Hill Guest Star Winston Story Guest Star Joseph Williamson Guest Star Payton Silver Guest Star Wayne Lopez Guest Star Shi Ne Nielson Guest Star Mac Brandt Guest Star Tim Chiou Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Rob Corn Director