Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Jessica Capshaw Dr. Arizona Robbins Actor Kim Raver Teddy Altman Actor Michael O'Neill Guest Star Tom Irwin Guest Star Robert Baker Guest Star Sarah Drew Guest Star Jesse Williams Jackson Avery Guest Star Nora Zehetner Guest Star Ryan Devlin Guest Star Mandy Moore Guest Star Jeanette Brox Guest Star Adam Shapiro Guest Star Jason Graham Guest Star Kelsey Scott Guest Star China Anderson Guest Star Moe Irvin Guest Star Gloria Garayua Guest Star Mark Saul Guest Star Ingrid Walters Guest Star Arlene Santana Guest Star