Rachel Bilson Dr. Zoe Hart Actor Jaime King Lemon Breeland Actor Wilson Bethel Wade Kinsella Actor Cress Williams Lavon Hayes Actor Scott Porter George Tucker Actor Tim Matheson Dr. Brick Breeland Actor Kaitlyn Black AnnaBeth Nass Actor Laura Bell Bundy Shelby Sinclair Guest Star Maree Cheatham Bettie Breeland Guest Star Valerie Mahaffey Mae Ellen Waterloo Guest Star Ian Anthony Dale Dr. Henry Dalton Guest Star Ross Philips Tom Long Guest Star Mallory Moye Wanda Long Guest Star Brandi Burkhardt Crickett Watts Guest Star Reginald VelJohnson Dash DeWitt Guest Star Steven M. Porter Frank Moth Guest Star Charlie Robinson Sergeant Jeffries Guest Star Erica Piccininni Jaysene Charles Guest Star Karla Mosley Elodie Baxter Guest Star Aynsley Bubbico Sadie Guest Star Christopher Curry Earl Kinsella Guest Star Matt Lowe Meatball Guest Star John Marshall Jones Wally Maynard Guest Star Nakia R. Burrise Patty Pritchett Guest Star Nicole J. Butler Prizzi Pritchett Guest Star Ben Giroux Little Zach Guest Star Leila Gerstein Executive Producer, Writer Josh Schwartz Executive Producer Stephanie Savage Executive Producer Len Goldstein Executive Producer Jason Ensler Executive Producer David Paymer Director