A young female patient desperately needs a heart as Kate (Kari Matchett) goes on a quest to find a donor. Meanwhile, Grant's mentor (Dabney Coleman) falls seriously ill; Grant vies to become the new chief surgeon; and Grant and Kate's daughter is caught shoplifting condoms.

Grant, now the chief of staff at the transplant center, considers a son's request to give part of his liver to his dying father. Meanwhile, Kate hopes to harvest organs from an unidentified homicide victim; an arrogant new doctor (Rockmond Dunbar) slips into Grant's old job; Simon performs his first solo surgery; and Thea stresses out over an approaching dance party.

Simon makes a serious mistake during transplant surgery, rendering a new liver ineffective. But another liver may become available via a living donor---the patient's brother, who is incarcerated for murder. Meanwhile, Grant forms a bond with a teen suffering from transplant complications.

Jonas prepares to perform a groundbreaking but risky uterine transplant on an infertile woman, but he must get consent from Grant, who's reluctant to approve the procedure and is instead consumed with saving a dying baby.

Kate and Jonas travel to West Virginia to procure a liver for a dying woman, but while there Jonas encounters racism. Elsewhere, Grant faces a deep ethical issue when a patient receives an illegal liver on the black market in Mexico; and Kate begins dating an IT man.

Grant and his team perform an intricate transplant procedure in which three married couples donate organs among themselves---and during which Mary must make a monumental sacrifice. Meanwhile, Jonas' wife arrives and the health of Jacobs (Dabney Coleman) continues to slip. Teria: Sundra Oakley.

An intense hostage crisis plays out at a video arcade, resulting in injuries and a possible organ donor. Meanwhile, Kate is tasked to train a new organ-recovery coordinator, and young Thea strives to gain more independence.

The health of Dr. Jacobs (Dabney Coleman) slips to critical. Meanwhile, Grant and Kate journey to Cincinnati on a mission to recover a lung---which puts Jonas in charge of the hospital. Jonas' immediate focus is to perform an intricate multi-visceral transplant, a procedure Grant originally rejected. Elsewhere, Simon desperately works to impress the staff in light of the imminent end of his fellowship.

In the series finale, Grant suffers a tragic personal loss. Elsewhere, a transplant crisis erupts when it's discovered a donor had cancer that was passed on to the organ recipients. Kate goes on a frantic mission to recover new organs.