Hugh Laurie Dr. Gregory House Actor Robert Sean Leonard Dr. James Wilson Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Odette Annable Dr. Jessica Adams Actor Charlyne Yi Dr. Chi Park Actor Karolina Wydra Dominika House Guest Star Michael B. Jordan Will Westwood Guest Star Margo Harshman Melissa Guest Star Diane Baker Blythe House Guest Star Billy Connolly Thomas Bell Guest Star John Montana Sam Guest Star Ryan Driscoll Stacy Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Tim Southam Director John C. Kelley Writer