Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor, Director Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Floriana Lima Miranda Riggs Guest Star Dan Warner Sam Guest Star Andrew Patrick Ralston Jim McNeile Guest Star Rex Linn Nathan Riggs Guest Star Kristen Lee Gutoskie Molly Guest Star Thomas Lennon Leo Getz Guest Star Andrew Creer Zach Bowman Guest Star Martin Donovan Grant Davenport Guest Star Michelle Hurd Gina Santos Guest Star Hilarie Burton Karen Palmer Guest Star George Sharperson Monty Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer Steve Boyum Director Omar Madha Director Eric Laneuville Director Salli Richardson-Whitfield Director Maja Vrvilo Director John Behring Director Larry Teng Director Silver Tree Director Nick Copus Director