Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Mike Dopud Gregory Guest Star Brooke Nevin Sara Guest Star Huse Madhavji Dr. Paulo Guest Star Michelle Hurd Gina Santos Guest Star Hilarie Burton Karen Palmer Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer