Michael Sheen William Masters Actor, Producer Lizzy Caplan Virginia Johnson Actor Caitlin FitzGerald Libby Masters Actor Teddy Sears Dr. Austin Langham Actor Annaleigh Ashford Betty DiMello Actor Julianne Nicholson Guest Star Keke Palmer Guest Star Greg Grunberg Guest Star Jocko Sims Guest Star Johnny Sneed Guest Star Barry Watson Guest Star Renée Elise Goldsberry Guest Star Jeremiah Birkett Guest Star Sarah Silverman Guest Star Courtney B. Vance Guest Star Michelle Ashford Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Judith Verno Executive Producer Amy Lippman Executive Producer Keith Gordon Director Eileen Myers Writer