Seth MacFarlane Captain Ed Mercer Actor, Executive Producer Adrianne Palicki Commander Kelly Grayson Actor Penny Johnson Dr. Claire Finn Actor Scott Grimes Lieutenant Gordon Malloy Actor Peter Macon Lieutenant Commander Bortus Actor Halston Sage Chief Security Officer Alara Kitan Actor J. Lee Lieutenant John Lamarr Actor Mark Jackson Isaac Actor Chad L. Coleman Klyden Actor Norm Macdonald Yaphit, Yaphit Voice, Guest Star Victor Garber Admiral Halsey Guest Star Patrick Cox Ogre Guest Star Brian George Dr. Aronov Guest Star Christine Corpuz Janice Lee Guest Star Sean Cook Derek Guest Star Joel Swetow Krill Captain Guest Star Brannon Braga Executive Producer David A. Goodman Executive Producer Jason Clark Executive Producer Liz Heldens Executive Producer Jon Favreau Director