Roseanne Barr Roseanne Conner Actor John Goodman Dan Conner Actor Sarah Chalke Becky Conner-Healy Actor Michael Fishman D.J. Conner Actor Laurie Metcalf Jackie Harris Actor Glenn Quinn Mark Healy Guest Star Martin Mull Leon Carp Guest Star Sandra Bernhard Nancy Bartlett Thomas Guest Star James Pickens Jr. Chuck Mitchell Guest Star Florence Henderson Flo Guest Star Nicolas Meyst Guest Star Jim Turner Stu Mehlman Guest Star Selma Archerd Lucille Guest Star Anthony Geary Luke Spencer Guest Star Genie Francis Laura Spencer Guest Star Tom Arnold Guest Star Betsy Borns Writer Mike Gandolfi Writer Philip Charles MacKenzie Director