Christina Applegate Samantha Actor Jennifer Esposito Andrea Belladonna Actor Kevin Dunn Howard Actor Melissa McCarthy Dena Actor Tim Russ Frank Actor Barry Watson Todd Actor Jean Smart Regina Newly Actor Billy Zane Winston Funk Guest Star Adam DeVine Tyler Banks Guest Star Nora Dunn Cheryl Hainstock Guest Star Hahn Cho Doctor Guest Star Abdoulaye N'Gom African Methodist Minister Guest Star Denise Gossett Homeless Woman Guest Star Terrance Christopher Jones Teacher Guest Star Jean-Pierre Gillain Philippe Guest Star Donald Todd Executive Producer Peter Traugott Executive Producer Matthew Carlson Writer Joanna Kerns Director