Jeremy Irons Rodrigo Borgia Actor François Arnaud Cesare Borgia Actor David Oakes Juan Borgia Actor Holliday Grainger Lucrezia Borgia Actor Colm Feore Giuliano Della Rovere Actor Derek Jacobi Cardinal Orsini Actor Joanne Whalley Vanozza Actor Lotte Verbeek Giulia Farnese Actor Neil Jordan Executive Producer, Writer John Maybury Director