Josh Keaton Peter Parker, Spiderman Voice Lacey Chabert Gwen Stacy Voice Joshua LeBar Flash Thompson Voice Grey DeLisle Betty Brant, Sally Avril Voice Alanna Ubach Liz Allan Voice Vanessa Marshall Mary Jane Watson Voice James Arnold Taylor Harry Osborn, Green Goblin Voice Steve Blum Seymour O'Reilly Guest Voice Thom Adcox-Hernandez Phineas Mason, Tinkerer, Homunculi Guest Voice Nikki Cox Sable Manfredi, Silver Sable Guest Voice John DiMaggio Sandman, Hammerhead Guest Voice Jeff Bennett St. John Devereaux Guest Voice Dee Bradley Baker Curt Connors, Homunculi Guest Voice Clancy Brown Rhino, George Stacy Guest Voice Crispin Freeman Electro Guest Voice Irene Bedard Jean DeWolff Guest Voice Ben Diskin Eddie Brock Guest Voice Xander Berkeley Quentin Beck, Mysterio Guest Voice Alan Rachins Norman Osborn Guest Voice Peter MacNicol Master Planner, Dr. Octopus Guest Voice Victor Cook Director Stan Lee Writer Matt Wayne Writer