Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ryan Phuong Tam Guest Star Craig T. Nelson Dale Guest Star Sarah Baker Ms. Hutchins Guest Star Doc Farrow Coach Wilkins Guest Star Ava Allan Jana Guest Star Katherine Von Till Local TV Newscaster Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Eric Kaplan Writer Connor Kilpatrick Writer Steve Holland Writer Maria Ferrari Writer Chris Koch Director