Kathy Bates Iris Actor Sarah Paulson Hypodermic Sally Actor Evan Peters James March Actor Matt Bomer Donovan Actor Wes Bentley Detective John Lowe Actor Chloë Sevigny Dr. Alex Lowe Actor Denis O'Hare Liz Taylor Actor Cheyenne Jackson Will Drake Actor Angela Bassett Ramona Royale Actor Lady Gaga The Countess Actor Finn Wittrock Tristan Duffy Guest Star Mare Winningham Hazel Evers Guest Star Lily Rabe Aileen Wuornos Guest Star Christine Estabrook Marcy Guest Star John Carroll Lynch John Wayne Gacy Guest Star Ryan Murphy Executive Producer Brad Falchuk Executive Producer Tim Minear Executive Producer Bradley Buecker Executive Producer Jennifer Salt Executive Producer James Wong Executive Producer Alexis Martin Woodall Executive Producer