Roman Lutterotti Arthur Actor Bruce Dinsmore David Read, Binky Barnes Voice Daniel Brochu Buster Baxter Voice Ethan Pugiotto D.W. Actor Jodie Resther Francine Alice Frensky Voice Melissa Altro Muffy Voice Arthur Holden Mr. Ratburn Voice Victor Gilbert Carl Actor Max Friedman Cole Brain Voice Sonja Ball Jane Read Voice Holly G. Frankel Fern Walters Voice Ellen David Bitzi Baxter Voice Julie Lemieux Bud, Mrs. Compson Voice Joanna Noyes Grandma Thora Read Voice Greg Bailey Director, Producer Marc Brown Writer, Executive Producer Joe Fallon Writer Peter K. Hirsch Writer Dietrich Smith Writer Carol Greenwald Executive Producer