Gary Sinise Det. Mack "Mac" Taylor Actor Melina Kanakaredes Det. Stella Bonasera Actor Carmine Giovinazzo Det. Danny Messer Actor Anna Belknap Det. Lindsay Monroe Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Robert Joy Dr. Sid Hammerback Guest Star A.J. Buckley Adam Ross Guest Star Kimberly Pfeffer Nicole Garner Guest Star Stefanie Butler Heather Rollins Guest Star Sheryl Lee Ellen Garner Guest Star Mel Harris Julie Rollins Guest Star Sam Anderson Dr. Richards Guest Star Richard Tyson Frank Russo Guest Star Michael Grant Terry Matt Huxley Guest Star Mark Colson Kevin Green Guest Star Richard Varga Nicole's E.R. Doctor Guest Star Courtenay Taylor Nurse Evette Guest Star Angela Marsden Paramedic 1 Guest Star John Lorenzo Cabbie Guest Star Perry Kelly Paramedic 2 Guest Star Peter M. Lenkov Writer David Von Ancken Director