Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Ted Danson D.B. Russell Guest Star Navid Negahban Zane Kalim Guest Star Kirk Acevedo James Boyd Guest Star Farshad Farahat Omar Nizan Guest Star Tehmina Sunny Nailah Fayed Guest Star Megan Dodds Christine Whitney Guest Star Natalie Martinez Detective Jamie Lovato Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Steven Lilien Writer Bryan Wynbrandt Writer Eric Laneuville Director