Jane Seymour Dr. Michaela "Mike" Quinn Actor Joe Lando Byron Sully Actor Chad Allen Matthew Cooper Actor Jessica Bowman Colleen Cooper Actor Shawn Toovey Brian Cooper Actor Jonelle Allen Grace Actor Barbara Babcock Dorothy Jennings Actor Orson Bean Loren Bray Actor Frank Collison Horace Bing Actor Jim Knobeloch Jake Slicker Actor Geoffrey Lower Rev. Timothy Johnson Actor Henry G. Sanders Robert E. Actor Larry Sellers Cloud Dancing Actor Helene Udy Actor William Shockley Hank Claggerty Actor Ash Adams Preston A. Lodge III Actor Brandon Douglas Dr. Andrew Cook Actor Brandon Hammond Guest Star Michelle Bonilla Guest Star Phillip Van Dyke Guest Star Pat Skipper Guest Star Christopher Carroll Guest Star Billy Mayo Guest Star Patrice Pitman Quinn Guest Star Alexandria McKenzie Calabrese Guest Star Beth Sullivan Executive Producer Chuck Bowman Director Julie Henderson Writer