Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Natalie Dormer Jamie Moriarty Guest Star Andrew Howard Devon Gaspar Guest Star Faran Tahir Ramses Mattoo Guest Star Delphina Belle Kayden Fuller Guest Star Andy Murray John Clay Guest Star Romell Witherspoon Henchman Guest Star Dion Mucciacito Kelty Guest Star John Brummer Molina Guest Star Rachel Pickup Allison Fuller Guest Star Jeffrey Hawkins Detective Guest Star Donovan Christie Jr. Watson's Date Guest Star Robert Doherty Executive Producer, Writer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer, Writer Larry Teng Director