Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor, Director Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor James Frain Odin Reichenbach Actor John Noble Morland Holmes Guest Star Kristen Bush Annie Spellman Guest Star Charlie Semine Stewart Pringle, Wilson Kubiak Guest Star Jodi Long Mrs. Tseng Guest Star Roderick Hill Wesley Conrad Guest Star January LaVoy Chloe Guest Star Eric Elizaga Eldon Guest Star Kristoffer Cusick Gene Guest Star Rachael Holmes Antonia Guest Star Gabe Doran Propane Salesman Guest Star Lizbeth MacKay Mrs. Conrad Guest Star Robert Doherty Executive Producer Carl Beverly Executive Producer Sarah Timberman Executive Producer John Polson Executive Producer Jason Tracey Executive Producer Bob Goodman Writer