Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Millicent Martin Gertrude Moon Guest Star Anthony LaPaglia Simon Moon Guest Star Brian Stokes Mitchell Cam Winston Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer Mark Reisman Executive Producer Dan O'Shannon Executive Producer Sheldon Epps Director Lori Kirkland Baker Writer