Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer, Director John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Wendie Malick Ronee Lawrence Guest Star Laura Linney Charlotte Guest Star Felicity Huffman Julia Wilcox Guest Star James Oliver Waiter Guest Star Julia Sweeney Ann Hodges Guest Star Aaron Eckhart Frank Guest Star Edward Hibbert Gil Chesterton Guest Star Lisa Thornhill Caroline Guest Star Marisa Guterman Andi Guest Star Tom McGowan Kenny Daly Guest Star Bill Kirchenbauer Wayne Guest Star Amita Balla Waitress Guest Star Bernadette Birkett Janelle Guest Star Victor Alfieri Esteban de Rojo Guest Star Estelle Parsons Celeste's Mother Guest Voice David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer, Director Mark Reisman Executive Producer Dan O'Shannon Executive Producer Sheldon Epps Director Scott Ellis Director Katy Garretson Director Jon Sherman Writer Sam Johnson Writer Bob Daily Writer Chris Marcil Writer Jeffrey Richman Writer Patricia Breen Writer Joe Keenan Writer Heide Perlman Writer Lori Kirkland Baker Writer