Kelsey Grammer Dr. Frasier Crane Actor, Executive Producer John Mahoney Martin Crane Actor Jane Leeves Daphne Moon Actor David Hyde Pierce Dr. Niles Crane Actor Peri Gilpin Roz Doyle Actor Felicity Huffman Julia Wilcox Guest Star Debra Monk Nurse Karen Guest Star Nancy Becker Kennedy Dana Guest Star Reichen Lehmkuhl Impossibly Handsome Man Guest Star Tom McGowan Kenny Daly Guest Star David Angell Executive Producer Peter Casey Executive Producer David Lee Executive Producer, Director Mark Reisman Executive Producer Dan O'Shannon Executive Producer Bob Daily Writer