Sophia Bush Dr. Sam Griffith Actor Jason Isaacs Dr. Rob "Griff" Griffith Actor Skye P. Marshall Dr. Lex Trulie Actor Michael Stahl-David Dr. Caleb Tucker Actor Davi Santos Dr. Joey Costa Actor Omar Maskati Dr. Isan M. Shah Actor Wendy Crewson Vivian Katz Actor Edwin Hodge Malcolm A. Kingsley Actor Sendhil Ramamurthy Asher Pyne Guest Star Victoria Rowell Tina Kingsley Guest Star Marium Carvell Nurse Donna Williams Guest Star Evan Parke Byron Kingsley Guest Star Bethany Joy Lenz Amy Taylor Guest Star Hilarie Burton Gretchen Taylor Guest Star Rong Fu Dr. Stacey Lee Guest Star Ronica Sajnani Mrs. Jain Guest Star Sylvan Valladares Vinit Jain Guest Star Marcus Nance Dr. Andre Markov Guest Star Katie Wech Executive Producer Jennie Snyder Urman Executive Producer Joanna Klein Executive Producer Frank Siracusa Executive Producer John Weber Executive Producer Jeremy Svenson Writer Oz Scott Director