Sophia Bush Dr. Sam Griffith Actor Jason Isaacs Dr. Rob "Griff" Griffith Actor Skye P. Marshall Dr. Lex Trulie Actor Michael Stahl-David Dr. Caleb Tucker Actor Davi Santos Dr. Joey Costa Actor Omar Maskati Dr. Isan M. Shah Actor Wendy Crewson Vivian Katz Actor Edwin Hodge Malcolm A. Kingsley Actor Marium Carvell Nurse Donna Williams Guest Star Stephen Tracey Tim Davis Guest Star Douglas E. Hughes Bernie Guest Star Indy Saluja Dr. Bhatt Guest Star Pearl Sun Nurse Opal Guest Star Ian Ho Kevin Dunn Guest Star Ipsita Paul Gladys Bridges Guest Star Donzaleigh Abernathy Carla Guest Star Maggie Huculak Dorothy Guest Star Christina Song Cathy Dunn Guest Star Matt Medrano Randy Dunn Guest Star Sangita Patel News Anchor Guest Star Adolyn Dar Dr. Raina Guest Star Andrea Cabeza Isabel Alvarez Guest Star Katie Wech Executive Producer Jennie Snyder Urman Executive Producer Joanna Klein Executive Producer Frank Siracusa Executive Producer John Weber Executive Producer Sara Casey Writer Manuel Herrera Writer Tessa Blake Director