Hugh Laurie Dr. Gregory House Actor Robert Sean Leonard Dr. James Wilson Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Odette Annable Dr. Jessica Adams Actor Charlyne Yi Dr. Chi Park Actor Karolina Wydra Dominika House Guest Star Rena Sofer Marlene Reese Guest Star Jake Weber Joe Reese Guest Star José Zúñiga Nate Weinmann Guest Star John Gloria Calvin Ayres Guest Star Duane Shepard Sr. Hastings Guest Star Mykee Selkin Staff Member Guest Star Denny Siegel Diane Guest Star Joseph Falasca Phil Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Colin Bucksey Director Liz Friedman Writer Sara Hess Writer