Hugh Laurie Dr. Gregory House Actor Robert Sean Leonard Dr. James Wilson Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Peter Jacobson Dr. Chris Taub Actor Odette Annable Dr. Jessica Adams Actor Charlyne Yi Dr. Chi Park Actor Olivia Wilde Thirteen, Dr. Remy Hadley Guest Star Skylar Astin Derrick Guest Star Moira Squier Jen Guest Star Natalie Dreyfuss Courtney Guest Star Derek Mio Floyd Guest Star Enzo Cilenti Matt Johnson Guest Star Joshua Rush Ryan Guest Star Jacob Zachar Mikey Guest Star David Wells Milton Guest Star Lyn Alicia Henderson Vet Guest Star David Danino Janitor Guest Star David Fraioli Janitor 2 Guest Star Pat McNeely Woman Guest Star Michael Christian Alexander Man Guest Star Brayden Brooks 6-Year-Old Christopher Guest Star Lindsay Dennis Cheerleader Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Miguel Sapochnik Director Russel Friend Writer Garrett Lerner Writer David Foster Writer