Damon Wayans Roger Murtaugh Actor Clayne Crawford Martin Riggs Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Kevin Rahm Captain Brooks Avery Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Floriana Lima Guest Star Toni Trucks Guest Star Sprague Grayden Guest Star Gino Anthony Pesi Guest Star Peter Cortes Guest Star Adrian Bustamante Guest Star Tony Plana Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer