Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Maggie Lawson Natalie Flynn Guest Star Richard Roundtree Don Bennett Guest Star Tom Musgrave Rodney Guest Star Stephen Friedrich Mateo Peralto Guest Star Erica Piccininni Bridget Guest Star Ronnie Gene Blevins Petros Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer