Emma Roberts Chanel Oberlin Actor Jamie Lee Curtis Dean Cathy Munsch Actor, Director Lea Michele Hester Actor Abigail Breslin Chanel No. 5 Actor Billie Lourd Chanel No. 3 Actor Keke Palmer Zayday Williams Actor John Stamos Dr. Brock Holt Actor Taylor Lautner Dr. Cassidy Cascade Actor James Earl Chamberlain Jackson Actor Kirstie Alley Nurse Hoffel Actor Niecy Nash Guest Star Glen Powell Guest Star Jerry O'Connell Guest Star Laura Bell Bundy Guest Star Andy Erikson Guest Star Colton Haynes Guest Star Trilby Glover Guest Star Riley McKenna Weinstein Guest Star Kevin Bigley Guest Star Alec Mapa Guest Star Ryan Murphy Executive Producer Brad Falchuk Executive Producer Ian Brennan Executive Producer Alexis Martin Woodall Executive Producer