Patrick Wilson Dr. Michael Holt Actor Jennifer Ehle Anna Paul Actor Margo Martindale Rita Perkins-Hall Actor Pablo Schreiber Anton Little Creek Actor Rachelle Lefevre Dr. Kate Sykora Actor Rhys Coiro Dr. Zeke Barnes Guest Star Afton Williamson Autumn Guest Star Adrian Martinez Hector Guest Star Lance Chantiles-Wertz Dante Crim Guest Star Becky Ann Baker Mary Polanco Guest Star Laura Jordan Theresa Crim Guest Star Chris Sullivan Biker Guest Star Antwayn Hopper Marty Polanco Guest Star Quincy Chad Nervous Husband Guest Star Chinasa Ogbuagu Paramedic Guest Star Maria Farrow Surgeon 1 Guest Star Christopher J. Winfree Surgeon 2 Guest Star Susannah Grant Executive Producer Jonathan Demme Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Neal Baer Executive Producer Dawn DeNoon Writer John David Coles Director