Seth MacFarlane Stan Smith, Roger Voice Wendy Schaal Francine Smith Voice Rachael MacFarlane Hayley Smith Voice Scott Grimes Steve Smith Voice Dee Bradley Baker Klaus Voice Lou Diamond Phillips Rusty Guest Voice Jeff Fischer Jeff Fischer, Glenn Guest Voice Ed Asner Grandpa Smith Guest Voice Tonantzin Carmelo Sooleawa'uha Guest Voice Danny Cistone Guest Voice Matt E. Mixer Guest Voice J.B. Smoove Airport Security Guard Guest Voice Joe Daniello Director Murray Miller Writer Judah Miller Writer