Seth MacFarlane Stan Smith, Roger Voice Wendy Schaal Francine Smith Voice Rachael MacFarlane Hayley Smith Voice Scott Grimes Steve Smith Voice Dee Bradley Baker Klaus Voice Burt Reynolds Sen. Buckingham Guest Voice Patrick Stewart Avery Bullock Guest Voice Mike Barker Hazmat Worker Guest Voice Jon Fener Guest Voice Jenifer Lewis Lessie Guest Voice Masasa Moyo Massage Therapist, Gang Leader Guest Voice Ron Perlman Monster Hunter Guest Voice Kevin Michael Richardson Principal Lewis Guest Voice Azura Skye Cookie Guest Voice Randy Spears John Q. Mind Guest Voice Rodney Clouden Director Brian Boyle Writer