Upon returning to San Francisco, Mary Ann is reunited with her daughter, Shawna, and ex-husband Brian 20 years after leaving them to pursue her career. As she flees the midlife crisis that arose from her seemingly perfect Connecticut life, Mary Ann returns to her home, where she is quickly drawn back in by Anna Madrigal and her chosen family, queer young residents of 28 Barbary Lane, a boardinghouse-turned-apartment complex that is owned by Anna. This limited series is a sequel to the 1993 miniseries and is inspired by the "Tales of the City" book series by Armistead Maupin. Laura Linney and Olympia Dukakis reprise their roles from the original TV production.