Kelsey Grammer Mayor Tom Kane Actor Connie Nielsen Meredith Kane Actor Jeff Hephner Ben Zajac Actor Kathleen Robertson Kitty O'Neil Actor Francis Guinan Gov. McCall Cullen Actor Troy Garity Sam Miller Actor Martin Donovan Ezra Stone Actor Hannah Ware Emma Kane Actor Rotimi Darius Morrison Actor T.I. Trey Rogers Guest Star Sanaa Lathan Mona Fredricks Guest Star Amy Morton Catherine Walsh Guest Star Daniel J. Travanti Gerald 'Babe' McGantry Guest Star Karen Aldridge Dr. Ella Harris Guest Star Marin Ireland Claire Mann Guest Star James Vincent Meredith Alderman Ross Guest Star John Hoogenakker Doyle Guest Star Anthony Mockus Sr. Mayor Rutledge Guest Star Nicole Forester Maggie Zajac Guest Star José Antonio García Galvez Guest Star Mary Hollis Inboden Jackie Guest Star Bruce Jarchow Carpenter Guest Star Anish Jethmalani Male Nurse Guest Star Brian King Chuck Guest Star Stephenie Park Receptionist Guest Star Rebecca Spence Tina Guest Star Phillip Edward Van Lear Alderman Alverson Guest Star Celeste Williams Karen Guest Star Marisol Doblado Prostitute Guest Star